Diagnostic value of serum Troponin T measurements using EIA method in Acute Myocardial Infarction.
- Author:
Yoon Jeong KIM
;
Dal Sik KIM
;
Hye Soo LEE
;
Sam Im CHOI
- Publication Type:Original Article
- MeSH:
Adult;
Angina Pectoris;
Cardiovascular Diseases;
Chest Pain;
Discrimination (Psychology);
Humans;
Myocardial Infarction*;
Reference Values;
Serologic Tests;
Troponin T*;
Troponin*
- From:Korean Journal of Clinical Pathology
1997;17(4):553-559
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
BACKGROUND: Cardiac troponin T (cTnT) is a new serological marker for use as a diagnostic toots for acute myocardial infarction (AMI). This study was designed to evaluate tee diagnostic efficiency of troponin T in AMI. METHODS: We determined the reference range of troponin T in 20 healthy adults without previous cardiovascular diseases and chest pain. We evaluated troponin-T, CK, LD, AST and CK-MB in serum of 13 AMI and 5 angina pectoris patients. The patients were arrived at the hospital within 3 hours after onset of (most recent) acute symptoms. Samples were drawn individually at the times of 0, 1, 3, 7, 18 and 24 hours after admission and continued at 6-h intervals for 2 days and 24-h intervals fort 2 weeks. Troponin T was determined by an enzyme-linked immuno-sorbent assay (one step sandwich assay) on an ES-300 analyzer. RESULTS: We found that serum troponin-T concentrations in healthy control adults were below 0.07microgram/L. The peak level of troponin-T concentration of patients with AMI was 22.0microgram/L, mean value, at 7 hours after admission and showed 110 times its discrimination limit value (0.2microgram/L). CK-MB value was normalized within 3 days after admission, but cTnT value remained high above its discrimination limit value until 2 weeks after admission during this study. CONCLUSIONS: The data indicate that the measurement of serum cTnT improves efficiency of serological testings of AMI as compared with conventionally used cardiac enzymes.
