Two Cases of Meningitis Caused by Penicillin-and Cephalosporin-resistant Streptococcus pneumoniae.
- Author:
Sun Hwa LEE
;
Yang Soo KIM
;
Eun Ok KIM
;
Jun Hee WOO
;
Jiso RYU
;
Chik Hyun PAI
- Publication Type:In Vitro ; Case Report
- MeSH:
Cefotaxime;
Ceftriaxone;
Cephalosporins;
Drug Resistance, Microbial;
Humans;
Meningitis*;
Meningitis, Bacterial;
Penicillin Resistance;
Penicillins;
Pneumonia;
Streptococcus pneumoniae*;
Streptococcus*;
Vancomycin
- From:Korean Journal of Clinical Pathology
1997;17(4):629-635
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Penicillin resistance in Streptococcus pneumoniae has increased sharply within the past few years and extended-spectrum cephalosporins haute been recommended for the empiric therapy of bacterial meningitis. However, therapeutic failure are being reported with increasing frequency due to extended-spectrum cephalosporin-resistant strains. We report two cases of meningitis caused by S. pneumoniae resistant to penicillin and cefotaxime. Both patients were recovered after ceftriaxone and vancomycin treatment, but one of them was left with neurological sequelae because of a delay in the institution of an antibiotic therapy appropriate for resistant pneumococci. This report indicates that extended-spectrum cephalosporin-resistance must be considered In all clinical isolates of S. pneumoniae and in vitro susceptibility testings should be performed promptly and accurately to detect antibiotic resistance.
