The Role of Basic Fibroblast Growth Factor in Moyamoya Disease.
- Author:
Dong Seok KIM
1
;
Joong Uhn CHOI
;
Se Hyuk KIM
;
Kook Hee YANG
;
Hyeun Sook KIM
Author Information
1. Department of Neurosurgery, Yonsei University College of Medicine, Seoul, Korea.
- Publication Type:Original Article
- Keywords:
Angiogenesis;
Basic fibroblast growth factor;
Encephalo-duro-arterio-synangiosis;
Moyamoya disease
- MeSH:
Enzyme-Linked Immunosorbent Assay;
Fibroblast Growth Factor 2*;
Fibroblasts;
Humans;
Moyamoya Disease*
- From:Journal of Korean Neurosurgical Society
2001;30(1):5-11
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
OBJECTIVES AND OMPORTANCE: The present study investigated the levels of basic fibroblast growth factor(bFGF) in the CSF of patients with moyamoya disease and its clinical significance. METHODS: The levels of bFGF in CSF, taken from 26 hemispheres of 14 moyamoya patients and 20 patients without vascular anomaly(control group), were measured by an enzyme-linked immunosorbent assay. We analyzed the correlation between the level of bFGF and the clinical factors such as age, onset pattern, development of neovascularization, and cerebral circulation. RESULTS: The CSF of moyamoya patients contained a high concentration of bFGF to a significant extent. The bFGF level was apparently elevated in the patients in whom neovascularization from indirect revascularization, such as modified encephalo-duro-arterio-synangiosis(EDAS) was well developed. A linear correlation between the values of bFGF and clinical progression was noted. CONCLUSIONS: The elevation of bFGF in moyamoya disease seems to be specific. Clinically, the bFGF level may be considered a useful indicator to predict the efficacy of indirect revascularization.
