Prognostic Significance of Preoperative Blood Transfusion in Stomach Cancer.
10.5230/jgc.2010.10.4.196
- Author:
Seok Hwan KIM
1
;
Sang Il LEE
;
Seung Moo NOH
Author Information
1. Department of Surgery, Research Institute for Medical Science, Chungnam National Universuty School of Medicine, Daejeon, Korea. seungnoh@cnu.ac.kr
- Publication Type:Original Article
- Keywords:
Stomach neoplasm;
Blood transfusion;
Prognosis
- MeSH:
Aspirin;
Blood Transfusion;
Gastrectomy;
Humans;
Multivariate Analysis;
Neoplasm Metastasis;
Preoperative Period;
Prognosis;
Retrospective Studies;
Stomach;
Stomach Neoplasms;
Survival Rate;
Ticlopidine
- From:Journal of Gastric Cancer
2010;10(4):196-205
- CountryRepublic of Korea
- Language:English
-
Abstract:
PURPOSE: We did a retrospective study to understand the prognostic effects of preoperative blood transfusions in stomach cancer surgery. MATERIALS AND METHODS: Data for 1,360 patients who underwent gastrectomy for stomach cancer between 2001 and 2009 were retrospectively reviewed. We analyzed factors that affect preoperative transfusion and clinicopathologic features. We also analyzed 5-year and overall survival rates of the transfusion and non transfusion subgroups. RESULTS: Sixty patients (4.4%) required blood transfusion within the preoperative period. The transfused group included patients who took aspirin or clopidogrel (P<0.001), with more advanced T stages (P<0.001), with more advanced nodal metastasis (P=0.00), and with more advanced stages (P=0.00) than the non transfusion group. On multivariate analysis, preoperative transfusion was a statistically significant negative influence on 5-year survival and overall survival rates (58.2% vs 79.9% (P=0.00), 58.2% vs 76.8% (P=0.00)). Applying Cox-regression analyses, blood transfusion did appear to have an effect on prognosis and on 5-year and overall survival rates. CONCLUSIONS: We found a direct negative relation between preoperative transfusion and long term prognosis in patients receiving gastric cancer surgery.
