Deep Brain Stimulation: Technology at the Cutting Edge.
- Author:
Rahul S SHAH
1
;
Su Youne CHANG
;
Hoon Ki MIN
;
Zang Hee CHO
;
Charles D BLAHA
;
Kendall H LEE
Author Information
- Publication Type:Review
- Keywords: deep brain stimulation; Parkinson's disease; mechanism of action
- MeSH: Brain; Deep Brain Stimulation; Depression; Dystonia; Electrodes; Epilepsy; Neurotransmitter Agents; Obsessive-Compulsive Disorder; Parkinson Disease; Tourette Syndrome; Tremor
- From:Journal of Clinical Neurology 2010;6(4):167-182
- CountryRepublic of Korea
- Language:English
- Abstract: Deep brain stimulation (DBS) surgery has been performed in over 75,000 people worldwide, and has been shown to be an effective treatment for Parkinson's disease, tremor, dystonia, epilepsy, depression, Tourette's syndrome, and obsessive compulsive disorder. We review current and emerging evidence for the role of DBS in the management of a range of neurological and psychiatric conditions, and discuss the technical and practical aspects of performing DBS surgery. In the future, evolution of DBS technology may depend on several key areas, including better scientific understanding of its underlying mechanism of action, advances in high-spatial resolution imaging and development of novel electrophysiological and neurotransmitter microsensor systems. Such developments could form the basis of an intelligent closed-loop DBS system with feedback-guided neuromodulation to optimize both electrode placement and therapeutic efficacy.
