Polymorphisms of CDH9 and CDH10 in Chromosome 5p14 Associatedwith Autism in the Korean Population.
- Author:
Aeri LEE
1
;
Jung Won PARK
;
Min NAM
;
Hee Jung BANG
;
Jae Won YANG
;
Kyung Sik CHOI
;
Su Kang KIM
;
Joo Ho CHUNG
;
Kyu Bum KWACK
Author Information
1. Department of Biomedical Science, College of Life Science, CHA University, Seongnam, Korea. kbkwack@cha.ac.kr
- Publication Type:Original Article
- Keywords:
Autism Spectrum Disorder;
CDH9;
CDH10;
5p14;
Association study;
Polymorphism
- MeSH:
Alleles;
Autistic Disorder;
Child;
Autism Spectrum Disorder;
DNA;
Genotype;
Humans;
Logistic Models;
Phenothiazines;
Polymorphism, Single Nucleotide
- From:Journal of the Korean Academy of Child and Adolescent Psychiatry
2011;22(4):287-293
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
OBJECTIVES: The region of chromosome 5p14 is known to be associated with autism spectrum disorder (ASD). The cadherin9 (CDH9) and cadherin10 (CDH10) genes are located in the region of chromosome 5p14 and reported to be associated with ASD in the Caucasian population. We performed an association study to identify if single nucleotide polymorphisms (SNPs) located on the CDH9 and CDH10 genes are associated in the Korean population. METHODS: Genomic DNA was extracted from the blood of 214 patients with ASD and 258 controls. SNPs selected from two genes were genotyped using an Illumina Golden-Gate Genotyping assay with VeraCode technology. Statistical analysis was performed using SAS and Plink software. RESULTS: All controls and ASD patients were in Hardy-Weinberg equilibrium. In the results of logistic regression analyses for the genotype model and the chi-square test for the allele model, we found that SNPs on the CDH9 and CDH10 genes were not associated with ASD. CONCLUSION: Our data suggests that the CDH9 and CDH10 genes are not associated with ASD in the Korean population.
