The Discriminating Nature of Dopamine Transporter Image in Parkinsonism: The Competency of Dopaminergic Transporter Imaging in Differential Diagnosis of Parkinsonism: 123I-FP-CIT SPECT Study.
- Author:
Bom Sahn KIM
1
;
Sung June JANG
;
Jae Seon EO
;
Eun Kyung PARK
;
Yu Kyeong KIM
;
Jong Min KIM
;
Won Woo LEE
;
Sang Eun KIM
Author Information
1. Department of Nuclear Medicine, Seoul National University College of Medicine, Seoul, Korea. kse@snu.ac.kr
- Publication Type:Original Article
- Keywords:
dopamine transporter;
parkinsonism;
123I-FP-CIT;
Parkinson's disease;
binding potential
- MeSH:
Alzheimer Disease;
Dementia;
Diagnosis, Differential*;
Dopamine Plasma Membrane Transport Proteins*;
Dopamine*;
Essential Tremor;
Humans;
Lewy Bodies;
Multiple System Atrophy;
Occipital Lobe;
Parkinson Disease;
Parkinsonian Disorders*;
Polymerase Chain Reaction;
Putamen;
Tomography, Emission-Computed, Single-Photon*
- From:Nuclear Medicine and Molecular Imaging
2007;41(4):272-279
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
PURPOSE: The aim of this study was to evaluate the discriminating nature of 123I-FP-CIT SPECT in patients with parkinsonism. METHODS: 123I-FP-CIT SPECT images acquired from the 18 normal controls; NC (60.4+/-10.0 yr) and 237 patients with parkinsonism (65.9+/-9.2 yr) were analyzed. From spatially normalized images, regional counts of the caudate, putamen, and occipital lobe were obtained using region of interest method. Binding potential (BP) was calculated with the ratio of specific to nonspecific binding activity at equilibrium. Additionally, the BP ratio of putamen to caudate (PCR) and asymmetric index (ASI) were measured. RESULTS: BPs of NC (3.37+/-0.57, 3.10+/-0.41, 3.23+/-0.48 for caudate, putamen, whole striatum, respectively) had no significant difference with those of essential tremor; ET (3.31+/-0.64, 3.06+/-0.61, 3.14+/-0.63) and Alzheimer's disease; AD (3.33+/-0.60, 3.29+/-0.79, 3.31+/-0.70), but were higher than those of Parkinson's disease; PD (1.92+/-0.74,1.39+/-0.68, 1.64+/-0.68), multiple system atrophy; MSA (2.36+/-1.07, 2.16+/-0.91, 2.26+/-0.96), and dementia with Lewy body; DLB (1.95+/-0.72, 1.64+/-0.65, 1.79+/-0.66)(p<0.005). PD had statistically lower values of PCR and higher values of ASI than those of NC (p<0.005). And PD had significantly lower value of PCR, higher ASI and lower BP in the putamen and whole striatum than MSA (p<0.05). CONCLUSION: Dopamine transporter image of 123I-FP-CIT SPECT was a good value in differential diagnosis of parkinsonism.
