Effect of Early Statin Treatment in Patients with Cardiogenic Shock Complicating Acute Myocardial Infarction.
10.4070/kcj.2013.43.2.100
- Author:
Doo Sun SIM
1
;
Myung Ho JEONG
;
Kyung Hoon CHO
;
Youngkeun AHN
;
Young Jo KIM
;
Shung Chull CHAE
;
Taek Jong HONG
;
In Whan SEONG
;
Jei Keon CHAE
;
Chong Jin KIM
;
Myeong Chan CHO
;
Seung Woon RHA
;
Jang Ho BAE
;
Ki Bae SEUNG
;
Seung Jung PARK
Author Information
1. Department of Cardiovascular Medicine, Chonnam National University College of Medicine, Gwangju, Korea. myungho@chollian.net
- Publication Type:Original Article
- Keywords:
Angioplasty;
Myocardial infarction;
Shock
- MeSH:
Angioplasty;
Hospital Mortality;
Hospitalization;
Humans;
Hydroxymethylglutaryl-CoA Reductase Inhibitors;
Korea;
Myocardial Infarction;
Secondary Prevention;
Shock;
Shock, Cardiogenic
- From:Korean Circulation Journal
2013;43(2):100-109
- CountryRepublic of Korea
- Language:English
-
Abstract:
BACKGROUND AND OBJECTIVES: The benefit of early statin treatment following acute myocardial infarction (MI) complicated with cardiogenic shock (CS) has not been well studied. We sought to assess the effect of early statin therapy in patients with CS complicating acute MI. SUBJECTS AND METHODS: We studied 553 statin-naive patients with acute MI and CS (Killip class IV) who underwent revascularization therapy between November 2005 and January 2008 at 51 hospitals in the Korea Acute Myocardial Infarction Registry. Patients were divided into 2 groups: those who received statins during hospitalization (n=280) and those who did not (n=273). The influence of statin treatment on a 12-month clinical outcome was examined using a matched-pairs analysis (n=200 in each group) based on the propensity for receiving statin therapy during hospitalization. RESULTS: Before adjustment, patients receiving statin, compared to those not receiving statin, had a more favorable clinical profile, were less likely to suffer procedural complications, and more likely to receive adequate medical therapy. Patients receiving statin had lower unadjusted in-hospital mortality and composite rate of mortality, MI, and repeat revascularization at 12 months, which remained significantly lower after adjustment for patient risk, procedural characteristics, and treatment propensity. CONCLUSION: In CS patients with acute MI undergoing revascularization therapy, early statin treatment initiated during hospitalization was associated with lower rates of in-hospital death and 12-month adverse cardiac events.
