Various CC Chemokine in Nasal Polyps and the Effect on CC Chemokine by Antibiotic Treatment.
- Author:
Seung Geun YEO
1
;
Joong Saeng CHO
;
Chang Il CHA
;
Sang Won YOON
Author Information
1. Department of Otolaryngology, College of Medicine, Eul Ji University, Seoul, Korea. ysg4206@eulji.or.kr
- Publication Type:Original Article
- Keywords:
CC chemokine;
Nasal polyps;
Antibiotic effect
- MeSH:
Anti-Bacterial Agents;
Chemokine CCL3;
Chemokine CCL5;
Chemokines;
Chemokines, CC;
Humans;
Inflammation;
Nasal Obstruction;
Nasal Polyps*;
Turbinates
- From:Journal of Rhinology
2001;8(1, 2):11-15
- CountryRepublic of Korea
- Language:English
-
Abstract:
BACKGROUND AND OBJECTIVES: The cause of nasal polyp is unsure but inflammation is thought to be an important factor in the development of nasal poyps. CC chemokine is a powerful chemotactic cytokine for inflammatory cells. We designed this study to investigate whether specific CC chemokines are associated with different forms of nasal polyps and their changes according to antibiotic treatment. MATERIALS AND METHODS: Nasal polyp from patients with atopy (AP group, n=12) and without atopy (NP group, n=20) were sampled. Expressions of RANTES, eotaxin, MCP-2, MCP-3 and MIP-1alpha were studied by an immunohistochemical study. Specimens of non-allergic nasal turbinates were used as the control group from 14 patients who were operated for nasal blockage. All patients were divided into 2 groups. One group was treated with antibiotics for 10 days before operation. The other was non-treated. RESULTS: Between the NP and AP group, the ratio of stained cells except anti-MCP 2 monoclonal antibody in the AP group was more increased than that of the NP group. Among them, RANTES and eotaxin were increased significantly (p<0.05). There was a significant difference of the expression of 5 CC chemokines between the treated and non-treated groups (p<0.05). CONCLUSIONS: These results suggest that chemokines play an important role in the development of nasal polyps, and different kinds of chemokines can be involved according to the cause of nasal polyps and CC chemokines affected by antibiotic treatment.
