The Application of Bacterial Meningitis Score for Bacterial Meningitis and Enteroviral Meningitis in Pediatric Patients.
- Author:
Minhwan PARK
1
;
Sinjae KIM
;
Jung Sook YEOM
;
Ji Sook PARK
;
Eun Sil PARK
;
Ji Hyun SEO
;
Jae Young LIM
;
Hyang Ok WOO
;
Hee Shang YOUN
Author Information
1. Department of Pediatrics, Gyeongsang National University School of Medicine, Gyeongsang Institute of Health Science, Jinju, Korea. polo96@daum.net
- Publication Type:Original Article
- Keywords:
Bacterial meningitis;
Aseptic meningitis;
Bacterial meningitis score
- MeSH:
C-Reactive Protein;
Cerebrospinal Fluid;
Child;
Clinical Decision-Making;
Humans;
Infant;
Leukocyte Count;
Leukocytosis;
Meningitis*;
Meningitis, Aseptic;
Meningitis, Bacterial*;
Neutrophils;
Retrospective Studies;
Sensitivity and Specificity
- From:
Journal of the Korean Child Neurology Society
2017;25(1):39-43
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
PURPOSE: Bacterial meningitis score (BMS) has been introduced as a clinical predictive parameter for diagnosing cerebrospinal fluid (CSF) pleocytosis in children at very low risk of bacterial meningitis in the postconjugate vaccine era. This study aimed to examine the usefulness of the BMS and to identify an additional index to distinguish between enteroviral meningitis and bacterial meningitis. METHODS: We retrospectively included 289 patients with enteroviral meningitis and 10 patients with bacterial meningitis between the aged 2 months to 16 years. We applied the BMS to all the included patients, and compared the initial laboratory and clinical characteristics between the two groups. RESULTS: Of the 210 patients categorized as having a very low risk of bacterial meningitis based on BMS, 2 (1%) had bacterial meningitis, both of whom were younger than 3 months. The sensitivity, specificity, and negative predictive value of the BMS for bacterial meningitis were 80%, 72%, and 99%, respectively. Compared with patients with enteroviral meningitis, those with bacterial meningitis were younger (0.3 years vs. 5.0 years, P<0.01), had higher leukocyte count (530/mm³ vs. 43/mm³, P=0.04), neutrophil count (490/mm³ vs. 20/mm³, P<0.01), and protein level (106 mg/dL vs. 30 mg/dL, P<0.01) in the CSF, and increased serum C-reactive protein (CRP) level (79 mg/L vs. 4.5 mg/L, P<0.01). CONCLUSION: Although the BMS is a useful clinical predictive parameter for identifying children with CSF pleocytosis who are at very low risk of bacterial meningitis, it should be applied with caution in young infants. In addition to applying BMS, clinical parameters such as CSF profiles and serum CRP levels are useful in clinical decision making for the management of children with CSF pleocytosis.
