Studying influences of some factors on ability of release and trandermal absorption of fluocinolone acetonid
- Author:
Long Van Nguyen
- Publication Type:Journal Article
- Keywords:
fluocinolon acetonid
- MeSH:
Fluocinolone Acetonide;
Pharmacokinetics;
Pharmaceutical Preparations
- From:Pharmaceutical Journal
2000;291(7):14-17
- CountryViet Nam
- Language:Vietnamese
-
Abstract:
The influence of different ointment bases and percutaneous penetration enhancers on in vitro release and anti-inflammatory efficacy of Fluoci-nolone acetonide was studied. The rank order of release through dialysis membrane was as follow: PEG> gel CMC> gel HPMC> gel carbopol> emugel>emultion. The anti-inflammatory efficacy of Fluocinolone acetonide on hairless rat skin was as follow: gel HPMC+0.5% I-menthol>gel carbopol +0.5% I-menthol > gel carbopol +0.5% I-methol > gel carbopol > oleaginous bases.
