CREB-Phosphorylation as a Predictor of Therapeutic Response to Antidepressants.
- Author:
Yu Jin LEE
1
;
Shinn Won LIM
;
Soo Yeon KIM
;
Jae Won JUNG
;
Jin Woo KIM
;
Woo Jae MYUNG
;
Ji Hye SONG
;
Doh Kwan KIM
Author Information
1. Department of Neuropsychiatry, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea. paulkim@skku.edu
- Publication Type:Original Article
- Keywords:
CREB-phosphorylation;
Depression;
Predictors;
Therapeutic response
- MeSH:
Antidepressive Agents;
Depression;
Fluoxetine;
Humans;
Lymphocytes;
Response Elements
- From:Journal of Korean Geriatric Psychiatry
2010;14(1):38-43
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
OBJECTIVES: CREB (c-AMP response element binding protein) is known as a key mediator of the therapeutic response to antidepressants. We investigated the change of CREB-phosphorylation (pCREB) at the early point of the fluoxetine treatment to find out it can be a predictor for antidepressant response. METHODS: We evaluated the pCREB of T - lymphocyte nuclear extracts from 18 depressed patients at 0 and 1th week during fluoxetine treatment (20 mg/day). Responders were defined as the > or = 50% reduction of HAM-D score in 4 weeks. We compared the changes of pCREB at 0 and 1th week between responders and non-responders. RESULTS: The responders showed a significant increase of pCREB at week 1 compared with week 0. The HAM-D difference between week 0 and 4 was positively correlated with the change of pCREB response. CONCLUSION: These results suggest that the early change of pCREB in peripheral lymphocyte can predict the later response of antidepressant. The correlation showed pCREB directly reflects a response status to the antidepressant fluoxetine and clinical improvement.
