A missense polymorphism (rs11895564, Ala380Thr) of integrin alpha 6 is associated with the development and progression of papillary thyroid carcinoma in Korean population.
10.4174/jkss.2011.81.5.308
- Author:
Su Kang KIM
1
;
Dong Kwan KIM
;
In Hwan OH
;
Jeong Yoon SONG
;
Kee Hwan KWON
;
Bong Keun CHOE
;
Yong Ho KIM
Author Information
1. Kohwang Medical Research Institute, Kyung Hee University School of Medicine, Seoul, Korea.
- Publication Type:Original Article
- Keywords:
Integrins;
alpha 6 (ITGA6);
Papillary thyroid cancer;
Polymorphism;
Progression
- MeSH:
Alleles;
Carcinoma;
Factor IX;
Gene Frequency;
Genotype;
Humans;
Integrins;
Logistic Models;
Lymph Nodes;
Odds Ratio;
Polymorphism, Single Nucleotide;
Risk Factors;
Thyroid Gland;
Thyroid Neoplasms
- From:Journal of the Korean Surgical Society
2011;81(5):308-315
- CountryRepublic of Korea
- Language:English
-
Abstract:
PURPOSE: Integrins play crucial roles in the pathogenesis of papillary thyroid carcinoma (PTC). The aim of this study was to investigate whether two single nucleotide polymorphisms (SNPs) (rs2141698, -1687A/G; rs11895564, Ala380Thr) of the integrin alpha 6 (ITGA6) gene are associated with the development and clinicopathologic characteristics of PTC such as the size (<1 cm and > or =1 cm), number (unifocality and multifocality), location (one lobe and both lobes), extrathyroid invasion, and cervical lymph node metastasis. METHODS: We enrolled 104 PTC patients and 318 control subjects. Genotypes of each SNP were determined by direct sequencing. SNPStats, SNPAnalyzer, and Helixtree programs were used to evaluate odds ratios (ORs), 95% confidence intervals (CIs), and P-values. Multiple logistic regression models were performed to analyze genetic data. RESULTS: A missense SNP rs11895564 was associated with the development of PTC. The A allele frequency of rs11895564 was higher in PTC patients than in controls (13.5% vs. 7.1%; P = 0.005; OR, 2.04; 95% CI, 1.24 to 3.37). In the clinicopathologic characteristics, the A allele frequency of rs11895564 showed difference in the size (19.6% in <1 cm vs. 6.9% in > or =1 cm; P = 0.010; OR, 0.30; 95% CI, 0.12 to 0.75) and number (8.5% in unifocality vs. 20.8% in multifocality; P = 0.015; OR, 2.85; 95% CI, 1.23 to 6.59) of PTC. CONCLUSION: These results suggest that the A allele of rs11895564 (Ala380Thr) in ITGA6 may be a risk factor of PTC, and also contribute to the progression of PTC in the Korean population.
