-1438A/G Polymorphism of the 5-HT2A Receptor Gene in Korean and Han Chinese Patients with Schizophrenia.
- Author:
Jang Ho YI
1
;
Guang Zhe LI
;
Sheng Fu LI
;
Long Ren WU
;
Yong Gen CHUI
;
Ah Rang CHO
;
Joo Ho CHUNG
;
Hwan Il CHANG
Author Information
1. Hong Jae Neuropsychiatric Clinic, Seoul, Korea.
- Publication Type:Original Article
- Keywords:
Schizophrenia;
5-HT2A receptor gene;
-1438A/G polymorphism
- MeSH:
Asian Continental Ancestry Group*;
Genotype;
Humans;
Polymorphism, Restriction Fragment Length;
Polymorphism, Single Nucleotide;
Receptor, Serotonin, 5-HT2A*;
Schizophrenia*
- From:Journal of Korean Neuropsychiatric Association
2005;44(1):25-31
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
OBJECTIVES: The purpose of the present study was to investigate the association between -1438A/G polymorphism of 5-HT2A receptor gene and schizophrenia in Korean and Han Chinese population. METHODS: A sample of 184 Korean patients with schizophrenia and 96 Korean healthy normal controls and 96 Han Chinese patients with schizophrenia and 96 Han-Chinese healthy normal controls were genotyped for a single nucleotide polymorphism with in 5-HT2A receptor gene (promoter region, A-1438G) by Msp I Restriction Fragment Length Polymorphism (RFLP). RESULTS: There was no difference in allelic frequencies and genotype frequencies of -1438A/G polymorphism between Korean schizophrenics and controls (p=0.13) and Han Chinese schizophrenics and controls (p=0.40). Also, -1438A/G polymorphism did not show ethnical difference between Korean and Han Chinese controls. The Scale for the Assessment of Negative Symptoms (SANS) scores showed no significant differences between genotypes of -1438A/G polymorphism in both of Korean and Han Chinese schizophrenics. CONCLUSION: These results suggest that -1438A/G polymorphism of the 5-HT2A receptor gene is not causally related to the development of schizophrenia in Korean and Han Chinese population, and there no ethnic difference between Korean and Han Chinese population.
