A Family-based and Case-control Association Study of the Dopamine D5 Receptor Gene Polymorphism in Attention Deficit Hyperactivity Disorder.
- Author:
Tae Won PARK
1
;
Boong Nyun KIM
;
Myung Ho IM
;
Hee Jeong YOO
;
Daehee KANG
;
Soo Churl CHO
;
Il Han YOO
;
Eun Cheong CHO
;
So Young PAEK
;
Chi Un PAE
;
Young Ju SUH
Author Information
1. Research Institute of Clinical Medicine, Chonbuk National University, Jeonju, Korea.
- Publication Type:Original Article
- Keywords:
Attention Deficit Hyperactivity Disorder (ADHD);
Polymorphism;
Dopamine D5 receptor (DRD5)
- MeSH:
Alleles;
Attention Deficit Disorder with Hyperactivity*;
Bias (Epidemiology);
Case-Control Studies*;
Child;
Dinucleotide Repeats;
Dopamine*;
Haplotypes;
Humans;
Parents;
Receptors, Dopamine D5*
- From:Journal of Korean Neuropsychiatric Association
2005;44(1):32-40
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
OBJECTIVES: Recent genetic studies have suggested a preferential transmission of the Dopamine D5 receptor gene (DRD5) 148bp marker allele. The aim of this study is to test the association between DRD5 and ADHD. METHODS: 106 Korean children with ADHD and their parents were analyzed using the transmission disequilibrium test (TDT) and haplotype-based haplotype relative risk test (HHRR). And also the ADHD children were compared with 212 age and gender matched normal controls. RESULTS: We found the evidence for an association of short alleles of DRD5 dinucleotide repeat polymorphism in both case control and family based studyies. Additionally, we observed some evidence for biased transmission of allele 152 bp and 144 bp. CONCLUSION: Our results lend credence to the notion that the relationship between ADHD and DRD5 is complex. The number of cases and informative transmissions in our study were small, therefore it would be premature to make any conclusions concerning the role of DRD5 in ADHD. Further work is needed to support these findings.
