The Relationship between Depression and Alcoholism: A Meta-Analysis.
- Author:
Sang A KIM
1
;
Chung Mo NAM
;
Woong Sub PARK
Author Information
1. Institute of Medical Science, Kwandong University College of Medical, Gangneung, Korea.
- Publication Type:Meta-Analysis ; Original Article
- Keywords:
Meta-analysis;
Depression;
Alcoholism
- MeSH:
Alcoholism*;
Depression*;
Odds Ratio;
Publication Bias
- From:Journal of Korean Neuropsychiatric Association
2005;44(1):75-81
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
OBJECTIVES: This study was designed to integrate the results of community based studies which assessed a relationship between depression and alcoholism by meta-analysis. METHODS: We identified the previons studies and included in meta-analysis by searching MEDLINE. Overall, 21 results of the studies for relationship between depression and alcoholism were selected for quantitative meta-analysis. Before the integration of the each effect size of the relationship between depression and alcoholism, a homogeneity test was conducted. For the publication bias, we also conducted the analyses of funnel plot, normal quantile plot, rank correlation test and the fail-safe n. RESULTS: We used the random effect model to estimate the overall effect size, because the homogeneity of studies was rejected in a fixed effect model. Our quantitative meta-analysis yielded that integrated odds ratio between depression and alcoholism was 2.42 (95% C.I. 1.98-2.97). From the results of analyses of the publication bias, the probability of publication bias is considered low. CONCLUSION: The published evidences suggested that there may be a significant positive relationship between depression and alcoholism.
