Effects of Haloperidol Decanoate Treatment on the Rat Brain: Morphological and Neurochemical Study.
- Author:
Young Chul CHUNG
1
;
Keon Hak LEE
;
Hong Bae EUN
;
Keun Young PARK
;
Tai Boong UHM
;
Hyoung Tae KIM
;
Eui Hyeog HAN
Author Information
1. Department of Psychiatry, Chonbuk National University, School of Medicine, Chonju, Korea.
- Publication Type:Original Article
- Keywords:
Haloperidol decanoate;
Rat striatum;
GABAnergic neurons;
Glutamate;
GABA
- MeSH:
Animals;
Appointments and Schedules;
Brain*;
gamma-Aminobutyric Acid;
Glutamic Acid;
Haloperidol*;
Incidence;
Mastication;
Models, Animal;
Neurons;
Rats*
- From:Korean Journal of Psychopharmacology
2000;11(2):136-144
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Using vacuous chewing movement(VCM) of rats as a possible animal model for tardive dyskinesia(TD), we tried to investigate the effects of haloperidol decanoate treatment on the rat brain: VCM(+) incidence, and morphological and neurochemical effect in the VCM(+) group. In our study, there were three treatment schedules of vehicle or haloperidol decanoate: 4, 7 or 9 total number of injections of vehicle or haloperidol decanoate were administered over 9, 18 or 24 weeks, respectively, with an injection given every 3 weeks. We rated VCM scores of rats at each injection time. Haloperidol groups were then further divided into VCM(-) rats and VCM(+) rats according to their VCM scores. Afterward, VCM(+) incidence was obtained in each haloperidol group. As time of neuroleptic treatment increased, the VCM scores and incidence of VCM(+) were found to be increased. All of the control, VCM(+) and VCM(-) rats were sacrificed to determine if treatments had morphological and neurochemical effects in the brain. Density of medium-sized neurons and levels of GABA in the striatum were reduced in the VCM(+) group 3 with total 9 injections given, compared to either VCM(-) group 3 or control group 3. These results suggest that hypofunction of GABAnergic neurons is associated with the development of VCM and possibly, TD.
