Wide QRS tachycardia during treatment with class ic antiarrhythmic agents in a patient with atrial fibrillation: report of 2 cases.
- Author:
Jae Kwang SHIM
1
;
Dong il LEE
;
Byung Il CHANG
;
Hyun Ju SHIN
;
Ki Hyun BYUN
;
Young Woo KIM
;
Jong Hyun KIM
Author Information
1. Division of Cardiology, Wallace Memorial Baptist Hospital, Busan, Korea. doctorsim@yahoo.co.kr
- Publication Type:Case Report
- Keywords:
Flecainide;
Propafenone;
Proarrhythmic effect;
Wide QRS tachycardia
- MeSH:
Atrial Fibrillation*;
Atrial Flutter;
Electrocardiography;
Flecainide;
Heart Rate;
Humans;
Propafenone;
Sodium Channels;
Tachycardia*
- From:Korean Journal of Medicine
2003;65(Suppl 3):S727-S732
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Wide QRS tachycardia may represent a rare proarrhythmic effect of some antiarrhythmic agents. Class Ic antiarrhythmic agents produce rate- dependent ventricular conduction slowing due to use-dependent sodium channel blockade, causing QRS prolongation in cases with an increased heart rate. The authors describe two cases of atrial flutter with 1:1 atrioventricular conduction exhibiting a wide QRS tachycardia while on therapy using flecainide and propafenone, and the difficulty in interpreting the ECG.
