Multivessel Thromboembolism Associated with Dysfunction of Protein S.
10.5535/arm.2012.36.3.414
- Author:
Eun Jae OK
1
;
Hye Won KIM
;
Sang Dong KIM
;
Kyoung Soo PARK
;
Yang Soo KIM
;
Ha Min KIM
;
Seong Hoon LIM
Author Information
1. Department of Rehabilitation Medicine, College of Medicine, The Catholic University of Korea, Suwon 442-723, Korea. seonghoon@catholic.ac.kr
- Publication Type:Case Report
- Keywords:
Protein S;
Thromboembolism;
Trans-tibial amputation
- MeSH:
Adult;
Amputation;
Angioplasty, Balloon;
Blood Coagulation Factors;
Female;
Heart Atria;
Humans;
Leg;
Lower Extremity;
Protein S;
Protein S Deficiency;
Pulmonary Embolism;
Reperfusion Injury;
Stress, Psychological;
Thrombectomy;
Thromboembolism;
Thrombosis;
Vitamins;
Young Adult
- From:Annals of Rehabilitation Medicine
2012;36(3):414-417
- CountryRepublic of Korea
- Language:English
-
Abstract:
Protein S is a vitamin K-dependent coagulation factor that acts as an anticoagulant. Deficiency of protein S increases the risk of thromboembolic events. We report a case of isolated protein S deficiency in a 39-year-old woman suffering arterial occlusion in both lower legs. She underwent a surgical procedure using thrombectomy and balloon angioplasty of her left lower extremity. Later, she had right trans-tibial amputation because of the reperfusion injury. Throughout the evaluation of thromboembolic events, we diagnosed a large thrombus in the right atrium and an asymptomatic pulmonary thromboembolism. The patient was successfully treated with right atrial thrombectomy and systemic anticoagulation. Careful evaluation for protein S levels may be necessary in patients with arterial thromboembolic events, especially young adults.
