From tumor hypoxia to cancer progression: the implications of hypoxia-inducible factor-1 expression in cancers.
- Author:
Fariz NURWIDYA
1
;
Fumiyuki TAKAHASHI
;
Kunihiko MINAKATA
;
Akiko MURAKAMI
;
Kazuhisa TAKAHASHI
Author Information
- Publication Type:Review
- Keywords: Tumor hypoxia; Cancer progression; Hypoxia-inducible factor-1
- MeSH: Anoxia; Genetic Processes; Humans; Neoplasm Metastasis; Oxygen; Prognosis; Transcription Factors
- From:Anatomy & Cell Biology 2012;45(2):73-78
- CountryRepublic of Korea
- Language:English
- Abstract: Hypoxia, defined as a decrease of tissue oxygen levels, represents a fundamental pathophysiological condition in the microenvironment of solid tumors. Tumor hypoxia is known to be associated with radio/chemo-resistance and metastasis that eventually lead to cancer progression contributing to poor prognosis in cancer patients. Among transcription factors that accumulated under hypoxic conditions, hypoxia-inducible factor-1 (HIF-1) is a master transcription factor that has received the most intense attention in this field of research due to its capacity to modulate several hundred genes. With a clearer understanding of the HIF-1 pathway, efforts are directed at manipulation of this complex genetic process in order to ultimately decrease cellular HIF-1 levels. Some novel agents have been shown to have HIF-1 inhibition activity through a variety of molecular mechanisms and have provided promising results in the preclinical setting.
