Gastric Adenocarcinoma of Fundic Gland Type: Report of Three Cases.
10.4132/KoreanJPathol.2012.46.3.287
- Author:
Eun Su PARK
1
;
Young Eun KIM
;
Cheol Keun PARK
;
Takashi YAO
;
Ryoji KUSHIMA
;
Kyoung Mee KIM
Author Information
1. Department of Hospital Pathology, Incheon St. Mary's Hospital, The Catholic University of Korea School of Medicine, Korea.
- Publication Type:Case Report
- Keywords:
Stomach neoplasms;
Fundic gland;
Chief cells, gastric;
Cell differentiation;
Pepsinogen A
- MeSH:
Male;
Humans;
Adenocarcinoma
- From:Korean Journal of Pathology
2012;46(3):287-291
- CountryRepublic of Korea
- Language:English
-
Abstract:
Recently, fundic gland type gastric adenocarcinoma (GA-FG) has been reported as a new entity. This report describes GA-FG among Koreans for the first time. From March 2008 to July 2010 we identified only three cases of GA-FG out of over 6,000 GAs resected by endoscopy or surgery. Cell differentiation by mucin proteins, pepsinogen-I, and H+/K+-ATPase was evaluated. All three cases were male patients and diagnosed as early stage GA. Histologically, GA-FGs were well-differentiated adenocarcinoma with pale gray-blue, basophilic columnar or cuboidal cells and mildly enlarged nuclei, resembling chief cells. All three cases were positive for pepsinogen-I and were classified as gastric mucin phenotype. Among three histologic subtypes of GA-FG, since tumors were mainly composed of chief cells, our three cases were classified as chief cell predominant type. In conclusion, GA-FG is very rare among Koreans and pepsinogen-I and MUC6 expression are typical immunohistochemical findings in GA-FG suggesting differentiation toward fundic glands.
