Plexiform Angiomyxoid Myofibroblastic Tumor of the Stomach: Report of Two Cases and Review of the Literature.
10.4132/KoreanJPathol.2012.46.3.292
- Author:
Youngran KANG
1
;
Wonkyung JUNG
;
In Gu DO
;
Eui Jin LEE
;
Min Hyeong LEE
;
Kyoung Mee KIM
;
Jongsang CHOI
Author Information
1. Department of Pathology, Korea University Guro Hospital, Korea University College of Medicine, Seoul, Korea.
- Publication Type:Case Report
- Keywords:
Angiomyxoid;
Stomach;
Myofibroblasts;
Plexiform;
Prognosis;
Review
- From:Korean Journal of Pathology
2012;46(3):292-296
- CountryRepublic of Korea
- Language:English
-
Abstract:
Plexiform angiomyxoid myofibroblastic tumor (PAMT) of the stomach is a recently recognized entity. Because of its rarity, only 22 cases have been reported in the English-language literature and most of these are single case reports. We report two cases of gastric PAMT. The tumor cells were bland and plexiform arranged in a myxoid stroma, which was positive for alcian blue. Immunohistochemically, the tumor cells were positive for smooth muscle actin, but negative for c-kit, CD34, desmin, S-100 protein, epithelial membrane antigen, neurofilament, and protein kinase C-theta. Mutation analyses for exon 9, 11, 13, and 17 of KIT genes and 12, 14, and 18 of the platelet-derived growth factor receptor alpha (PDGFRA) genes were performed and the tumors were wild-type for mutation.
