Inhibitory Effects of Resveratrol on Melanin Synthesis in Ultraviolet B-Induced Pigmentation in Guinea Pig Skin.
- Author:
Taek Hwan LEE
1
;
Jae Ok SEO
;
So Hyeon BAEK
;
Sun Yeou KIM
Author Information
1. College of Pharmacy, Yonsei University, Incheon 406-840, Republic of Korea.
- Publication Type:Original Article
- Keywords:
Resveratrol;
Depigmentation;
Hyperpigmentation;
Melanogenesis;
Guinea pig;
Ultraviolet B
- MeSH:
alpha-MSH;
Animals;
Biological Products;
Fruit;
Guinea Pigs*;
Hyperpigmentation;
Melanins*;
Melanoma;
Microphthalmia-Associated Transcription Factor;
Monophenol Monooxygenase;
Pigmentation*;
Skin*;
Vitis
- From:Biomolecules & Therapeutics
2014;22(1):35-40
- CountryRepublic of Korea
- Language:English
-
Abstract:
Resveratrol is a polyphenolic compound found in various natural products such as grapes and berries and possesses anti-cancer, anti-hyperlipidemia, and anti-aging properties. Recently, it has been reported that resveratrol inhibits alpha-melanocyte-stimulating hormone signaling, viability, and migration in melanoma cells. However, these effects have not been confirmed in vivo, specifically brownish guinea pigs. To evaluate the potential of resveratrol as a regulator of melanin for hyperpigmentation therapy, the influence of resveratrol on pigmentation was investigated by ultraviolet B-induced hyperpigmentation in brownish guinea pig skin. We found that resveratrol reduced the expression of melanogenesis-related proteins tyrosinase, tyrosinase-related proteins 1 and 2, and microphthalmia-associated transcription factor in melanoma cells. Furthermore, topical application of resveratrol was demonstrated to significantly decrease hyperpigmentation on ultraviolet B-stimulated guinea pig skin in vivo. Based on our histological data, resveratrol inhibits melanin synthesis via a reduction in tyrosinase-related protein 2 among the melanogenic enzymes. This study is the first to provide evidence supporting resveratrol as a depigmentation agent, along with further clinical investigation of resveratrol in ultraviolet B-induced skin disorders such as hyperpigmentation and skin photoaging.
