Early Sodium and Fluid Intake and Severe Intraventricular Hemorrhage in Extremely Low Birth Weight Infants.
10.3346/jkms.2015.30.3.283
- Author:
Hye Jin LEE
1
;
Byong Sop LEE
;
Hyun Jeong DO
;
Seong Hee OH
;
Yong Sung CHOI
;
Sung Hoon CHUNG
;
Ellen Ai Rhan KIM
;
Ki Soo KIM
Author Information
1. Department of Pediatrics, University of Ulsan College of Medicine, Asan Medical Center, Seoul, Korea. mdleebs@amc.seoul.kr
- Publication Type:Original Article
- Keywords:
Sodium;
Intraventricular Hemorrhage;
Hypernatremia;
Fluid Therapy;
Infant, Extremely Low Birth Weight;
Infant, Premature
- MeSH:
Birth Weight;
Dehydration;
Drinking;
Heart Ventricles/*pathology;
Hemorrhage/mortality/*pathology;
Humans;
Hypernatremia/*blood;
Infant;
Infant Mortality;
Infant, Extremely Low Birth Weight/*blood;
Infant, Newborn;
Infant, Premature;
Infant, Premature, Diseases/epidemiology;
Retrospective Studies;
Sodium/*blood;
Sodium, Dietary
- From:Journal of Korean Medical Science
2015;30(3):283-289
- CountryRepublic of Korea
- Language:English
-
Abstract:
Hypernatremic dehydration is an important cause of intracranial hemorrhage. A possible association of intraventricular hemorrhage (IVH) with hypernatremia and/or high sodium intake has been suggested in preterm infants. To investigate the associations of early fluid and sodium intake or serum sodium concentrations with severe intraventricular hemorrhage (IVH) in extremely low birth weight (ELBW) infants, we reviewed the medical records of 169 inborn ELBW infants. Daily fluid and sodium intake, urine output, weight loss and serum sodium concentration during the first 4 days of life were obtained. Patients were divided into the severe IVH (grade 3/4) and the control (no or grade 1/2 IVH) group. The maximum serum sodium concentration and the incidence of hypernatremia did not differ between the two groups. Related to the fluid balance and sodium intake, the risk for severe IVH was strongly associated with total fluid and sodium intake during the initial four days of life. With respect to the fluids other than transfusion, severe IVH can be discriminated only by sodium intake but not by fluid intake. Large randomized controlled trials are required to clarify the causal relationship between the early sodium intake and severe IVH in ELBW infants.
