Fermented antler extract enhances the viability and interleukin-12 production of spleen cells.
10.14405/kjvr.2016.56.3.183
- Author:
Hye Yeoul YANG
1
;
Youngsu KIM
;
Hong Gu JOO
Author Information
1. Laboratory of Veterinary Pharmacology, College of Veterinary Medicine, Jeju National University, Jeju 63243, Korea. jooh@jejunu.ac.kr
- Publication Type:Original Article
- Keywords:
fermented antler extract;
immunomodulation;
spleen cells
- MeSH:
Animals;
Antlers*;
Asian Continental Ancestry Group;
Cell Death;
Flow Cytometry;
Humans;
Immunity, Cellular;
Immunomodulation;
Interleukin-12*;
Lymphocytes;
Spleen*;
Tumor Necrosis Factor-alpha
- From:Korean Journal of Veterinary Research
2016;56(3):183-187
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
The effects of antlers have long been known in traditional Asian medicine. However, few studies have investigated the effects of antlers on immunity. In this study, we investigated whether fermented antler extract (FAE) has immunomodulatory effects on spleen cells. FAE enhanced the activity of spleen cells in a concentration dependent manner compared to antler extract. Interestingly, FAE significantly increased the production of interleukin-12, a representative cytokine of cell-mediated immunity, while it marginally increased that of tumor necrosis factor-alpha. Flow cytometry analysis demonstrated that FAE can protect spleen cells from spontaneous cell death without a significant proportional change in subsets, mainly lymphocytes. Taken together, the results of the present study showed that FAE has beneficial effects on spleen cells, a major type of immune cell, indicating that it can function as an immunomodulator without significant cytotoxicity. These data may broaden the use of FAE in basic research and clinical areas.
