Two Cases of Acquired Hypothyroidism with Severe Obesity, Short Stature and Cardiomegaly.
- Author:
So Young KANG
;
Woo Sung PARK
;
Mi Jin JUNG
;
Young Seok LEE
;
Seok Gun PARK
;
Jeesuk YU
- Publication Type:Original Article
- Keywords:
Acquired hypothyroidism;
Obesity;
Short stature;
Cardiomegaly
- MeSH:
Antibodies;
Cardiomegaly*;
Child;
Constipation;
Fatigue;
Humans;
Hyperlipidemias;
Hypothyroidism*;
Incidence;
Microsomes;
Myxedema;
Obesity;
Obesity, Morbid*;
Pericardial Effusion;
Peripheral Nervous System Diseases;
Puberty, Precocious;
Thyroid Function Tests;
Thyroid Gland;
Thyroxine
- From:Journal of Korean Society of Pediatric Endocrinology
2003;8(2):189-195
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
The clinical signs of acquired hypothyroidism are usually manifested insidiously over several months to years. The incidence increases after 6 years of age and peaks at 11 to 18 years of age. The clinical symptoms and signs are fatigue, constipation, decreased growth velocity and delayed bone age, compromised intellectual performance, obesity, myxedema, hyperlipidemia, peripheral neuropathy and delayed or precocious puberty. Two children were referred to our hospital for the evaluation of severe obesity and short stature. During the evaluation we found they also had hyperlipidemia, cardiomegaly with or without pericardial effusion. Thyroid function test revealed decreased serum thyroid hormone levels with positive anti- microsome and anti-thyroglobulin antibodies consistent with long-standing acquired hypothyroidism. After the supplement of L-thyroxine, both of them showed rapid improvement of above symptoms, except for the incomplete catch-up growth. We herein report two cases of acquired hypothyroidism with severe obesity, short stature, hyperlipidemia and cardiomegaly with review of literatures.
