Effects of Intra - Pulmonary Arterial Diltiazem on Hypoxic Pulmonary Vasoconstriction in Dogs.
10.4097/kjae.1992.25.3.468
- Author:
Seong Deok KIM
1
;
Chong Sung KIM
;
Hee Soo KIM
;
Seung Woon LIM
Author Information
1. Department of Anesthesiology, Seoul National University College of Medicine, Seoul, Korea.
- Publication Type:Original Article
- Keywords:
Hemodynamics;
Hypoxic pulmonary vasoconstrictions(HPV);
Diltiazem
- MeSH:
Animals;
Arterial Pressure;
Diltiazem*;
Dogs*;
Hemodynamics;
Hypertension;
Pulmonary Artery;
Vasoconstriction*
- From:Korean Journal of Anesthesiology
1992;25(3):468-476
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
In this study, we evaluated systemic and pulmonary hemodynamic changes with the administration of diltiazem into pulmonary artery in hypoxia(F1O2 0.15)-induced pulmonary vasoconstriction in 7 mongrel dogs. Hypoxic gas induced pulmonary vasoconstriction(HPV) resulted in 23.8% increase of mean pulmonary arterial pressure(PAP) without any changes of pulmonary vascular resistance(PVR). A 200 ug/kg intravenous bolus of diltazem, followed by 10 ug/kg/min(DL)and 15 ug/kg/min(DH) for 20 min, respectively, produced no change in pulmonary arterial pressure. But this was accompanied by increase in PVR and PVR/SVR ration in DL and 20 min after DH. We conclude that diltiazem does not seem to decrease acute hypoxic pulmonary vasoconstrition in dogs and it might not be beneficial drug for this kind of pulmoary hypertension.
