Protective Effects of Trimetazidine in a Rabbit Model of Transient Spinal Cord Ischemia.
- Author:
Ju Won CHOE
1
;
Mee Hea KIM
;
Tae Yun OH
;
Jin Soo HAN
;
Jong Sung KIM
;
Su Yun LEE
;
Woon Ha CHANG
Author Information
1. Department of Thoracic and cardiovascular surgery, Kangbuk Samsung Hospital, School of Medicine, Sungkyunkwan University, Seoul, Korea. WHChang123@hanmail.net
- Publication Type:Original Article
- Keywords:
Trimetazidine;
Spinal cord ischemia;
Aorta, Thoracoabdominal
- MeSH:
Aorta;
Aorta, Abdominal;
Aortic Diseases;
Constriction;
Ischemia;
Myocardial Ischemia;
Neuroprotective Agents;
Paraplegia;
Rabbits;
Renal Artery;
Spinal Cord Injuries;
Spinal Cord Ischemia*;
Spinal Cord*;
Trimetazidine*
- From:The Korean Journal of Thoracic and Cardiovascular Surgery
2002;35(4):255-260
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
BACKGROUND: Paraplegia remains unresolved as the most dreaded operative complication with surgical treatment of descending thoracic and thoracoabdominal aortic diseases. In this study, the neuroprotective effect of trimetazidine that has been used clinically for ischemic heart disease was investigated in a rabbit spinal cord ischemia model. MATERIAL AND METHOD: Thirty-three New Zealand white rabbits were randomized as follows: control group undergoing abdominal aortic occlusion but receiving no pharmacologic intervention(Group 1, n=17); TMZ group(Group 2, n=16) receiving 3 mg/kg trimetazidine intravenously before the occlusion of the aorta. Ischemia was induced by clamping the abdominal aorta just distal to the left renal artery for 30 minutes. Neurologic status was assessed at 2, 24, and 48 hours after the operation according to the modified Tarlov scale, then the lumbosacral spinal cord was processed for histopathologic examinations 48 hours after the final assessment. RESULT: The average motor function score was significantly higher in the TMZ group(3.20 +/- 0.77 vs 1.13 +/- 1.25 at 2 hours, 3.50 +/- 0.76 vs 1.45 +/- 1.57 at 24 hours, and 3.91 +/- 0.30 vs 1.86 +/- 1.86 at 48 hours after operation; p value
