Effects of Several Autonomic Drugs on the Responses to Electrical Stimulation of the Detrusor Muscle Strips in Amyda Japonica.
- Author:
Chun Kyu SONG
1
Author Information
1. Depatment of Urology, Capital Armed Forces General Hospital, Seoul, Korea.
- Publication Type:Original Article
- Keywords:
electrical stimulation;
detrusor muscle;
autonomic drugs
- MeSH:
Atropine;
Autonomic Agents*;
Baths;
Clonidine;
Electric Stimulation*;
Guanethidine;
Nerve Endings;
Neurotransmitter Agents;
Phentolamine;
Receptors, Adrenergic, alpha;
Tetrodotoxin
- From:Korean Journal of Urology
1981;22(1):7-11
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
A strip of the detrusor muscle of amyda japonica was provided in a bath which contained frog-Ringer's solution and the responses to electrical stimulation were observed by means of an isotonic myograph. The effects of several autonomic drugs on the responses to electrical stimulation of the strip were examined. The following results were obtained. 1. Electrical stimulation of the isolated detrusor muscle strip elicited contraction response and the response showed two peaks at 20 and 80 Hz between 1-200 Hz stimulation frequencies. 2. The responses to electrical stimulation of the detrusor muscle strip was completely abolished in the presence of tetrodotoxin and resumed after washing the bath fluids. 3. The responses to electrical stimulation of the detrusor muscle strip were significantly reduced in the presence of atropine, guanethidine, or regitine. 4. Clonidine did not affect the contraction response to electrical stimulation of the detrusor muscle strip. These results suggest that the detrusor muscle of Amyda japonica is innervated by both cholinergic and adrenergic nerves and it contains adrenergic alpha-receptors and that presynaptic alpha-adrenoceptors known to modify inhibit the release of neurotransmitters from the nerve endings are not involved.
