A Case of Overlapping Syndrome of Primary IgA Nephropathy and Membranous Nephropathy.
- Author:
Kyung Hyun KIM
1
;
Young Jun HA
;
Jae Woong HUR
;
Woo Jong SEO
;
Chan Su PARK
;
Joon Hwa SONG
;
Yong Jin KIM
Author Information
1. Department of Internal Medicine, Pohang St. Mary's Hospital, Pohang, Korea. imjhsong@zaigen.co.kr
- Publication Type:Case Report
- Keywords:
IgA nephropathy;
Membranous nephropathy;
Primary;
Overlapping nephropathy
- MeSH:
Angiotensin-Converting Enzyme Inhibitors;
Capillaries;
Diuretics;
Fluorescent Antibody Technique;
Glomerulonephritis, IGA*;
Glomerulonephritis, Membranous*;
Hematuria;
Hepatitis B;
Hepatitis C;
Humans;
Immune System Diseases;
Immunoglobulin A*;
Immunoglobulin G;
Middle Aged;
Proteinuria
- From:Korean Journal of Nephrology
2001;20(3):506-510
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
We report a rare case of primary glomerular disease with overlapping IgA nephropathy and membranous nephropathy in a 52 year-old man. Clinically, The patient showed microscopic hematuria and proteinuria and had no underlying disorders such as hepatitis B, hepatitis C, drug exposure, SLE or other immunologic diseases. Histologically, glomeruli showed focal cellular proliferartione and electron deposits in the mesangium and concomittant subepithelial deposits. Immunofluorescence revealed IgA depositions in a mesangium and IgG depositions along the glomerular capillary walls, like those of typical membranous nephropathy. These findings suggest the primary glomerular disease overlapping of two different glomerular changes. The patient showed still persistent proteinuria, but have preserved renal function with administrations of ACE inhibitors and diuretics after two years.
