Bilateral Renal Parenchymal Malacoplakia Presenting as Fever and Acute Renal Failure.
- Author:
Young Hoon JEONG
1
;
Duk Jae KIM
;
Jin Ho KIM
;
Hyun Ju LEE
;
Geun Doo JANG
;
Eun Kyoung KIM
;
Soon Bae KIM
;
Jae Gul CHUNG
;
Sang Koo LEE
Author Information
1. Department of Internal Medicine, University of Ulsan College of Medicine, Asan Medical Center, Seoul, Korea. sklee2@www.amc.seoul.kr
- Publication Type:Case Report
- Keywords:
Malacoplakia;
Fever;
Acute renal failure;
Steroid
- MeSH:
Acute Kidney Injury*;
Aged;
Anemia;
Anti-Bacterial Agents;
Ascorbic Acid;
Bethanechol;
Biopsy;
Diagnosis, Differential;
Fever*;
Humans;
Kidney;
Leukocytosis;
Macrophages;
Malacoplakia*;
Male;
Methylprednisolone;
Thrombocytopenia
- From:Korean Journal of Nephrology
2001;20(3):530-534
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Malacoplakia is a rare, chronic inflammatory disorder characterized by abnormal macrophage function and cell infiltration into normal tissues. We report a 72 year old male with bilateral renal parenchymal malacoplakia who presented with high fever and acute renal failure. The patient had anemia, leukocytosis, thrombocytopenia and bilateral nephromegaly with reduced renal function. Blood and urine cultures showed no micro-organisms. A kidney biopsy revealed diffuse interstitial histiocytic infiltration with intracellular inclusion bodies(Michaelis-Gutmann body). He was treated with antibiotics, and bethanechol, ascorbic acid without improvement. Following treatment with an intravenous methylprednisolone pulse therapy, clinical improvement was made. Renal parenchymal malacoplakia should be considered in the differential diagnosis when presented with high fever, enlarged kidneys and acute renal failure.
