The Search for Genetic Variants and Epigenetics Related to Asthma.
10.4168/aair.2011.3.4.236
- Author:
Shin Hwa LEE
1
;
Jong Sook PARK
;
Choon Sik PARK
Author Information
1. Genome Research Center for Allergy and Respiratory Disease, Division of Allergy and Respiratory Medicine, Soonchunhyang University Hospital, Bucheon, Korea. mdcspark@unitel.co.kr
- Publication Type:Review
- Keywords:
Asthma;
epigenetics;
gene;
genome;
linkage;
polymorphism;
variants
- MeSH:
Asthma;
Coat Protein Complex I;
Epigenomics;
Genetic Association Studies;
Genome;
Genome-Wide Association Study;
Polymorphism, Single Nucleotide
- From:Allergy, Asthma & Immunology Research
2011;3(4):236-244
- CountryRepublic of Korea
- Language:English
-
Abstract:
For the past two decades, a huge number of genetic studies have been conducted to identify the genetic variants responsible for asthma risk. Several types of genetic and genomic approaches, including linkage analysis, candidate gene single nucleotide polymorphism studies, and whole genome-wide association studies have been applied. In this review article, the results of these approaches are summarized, and their limitations are discussed. Additionally, perspectives for applying upcoming new epigenetic or genomic technologies, such as copy number variation, are introduced to increase our understanding of new omic approaches to asthma genetics.
