Assessment of Bronchodilator Responsiveness Following Methacholine-Induced Bronchoconstriction in Children With Asthma.
10.4168/aair.2011.3.4.245
- Author:
Siegfried BAUER
1
;
Ha Neul PARK
;
Hyeon Seok SEO
;
Ji Eun KIM
;
Dae Jin SONG
;
Sang Hee PARK
;
Ji Tae CHOUNG
;
Young YOO
;
Hyung Jin KIM
Author Information
1. Department of Pediatrics, College of Medicine, Korea University, Seoul, Korea. yoolina@korea.ac.kr
- Publication Type:Original Article
- Keywords:
Atopy;
asthma;
beta-adrenergic agonist;
child;
eosinophilia;
methacholine
- MeSH:
Adrenergic beta-Agonists;
Asthma;
Azides;
Bronchoconstriction;
Bronchodilator Agents;
Child;
Eosinophil Cationic Protein;
Eosinophilia;
Eosinophils;
Humans;
Immunoglobulin E;
Inhalation;
Methacholine Chloride;
Serotonin;
Skin
- From:Allergy, Asthma & Immunology Research
2011;3(4):245-250
- CountryRepublic of Korea
- Language:English
-
Abstract:
PURPOSE: The aim of this study was to investigate bronchodilator responsiveness (BDR) following methacholine-induced bronchoconstriction and to determine differences in BDR according to clinical parameters in children with asthma. METHODS: The methacholine challenge test was performed in 145 children with mild to moderate asthma, and the provocative concentration causing a 20% decline in FEV1 (PC20) was determined. Immediately after the challenge test, patients were asked to inhale short-acting beta2-agonists (SABAs) to achieve BDR, which was assessed as the change in FEV1% predictedx100/post-methacholine FEV1% predicted. For each subject, the asthma medication, blood eosinophil count, serum total IgE, serum eosinophil cationic protein level, and skin prick test result were assessed. RESULTS: The FEV1 (mean+/-SD) values of the 145 patients were 90.5+/-10.9% predicted, 64.2+/-11.5% predicted, and 86.2+/-11.2% predicted before and after methacholine inhalation, and following the administration of a SABA, respectively. The BDR did not differ significantly according to asthma medication, age, or gender. However, BDR in the atopy group (37.4+/-17.7%) was significantly higher than that in the non-atopy group (30.5+/-10.7%; P=0.037). Patients with blood eosinophilia (38.6+/-18.1%) displayed increased BDR compared with patients without eosinophilia (32.0+/-13.8%; P=0.037). CONCLUSIONS: In children with mild to moderate asthma, the responsiveness to short-acting bronchodilators after methacholine-induced bronchoconstriction was not related to asthma medication, but was higher in children with atopy and/or peripheral blood eosinophilia.
