The Relationship Between Serum 25 Hydroxy Vitamin D Levels and Asthma in Children.
10.4168/aair.2011.3.4.251
- Author:
Soheila ALYASIN
1
;
Tooba MOMEN
;
Sara KASHEF
;
Abbass ALIPOUR
;
Reza AMIN
Author Information
1. Division of Allergy and Immunology, Department of Pediatrics, Shiraz University of Medical Sciences, Shiraz, Iran. moment@sums.ac.ir
- Publication Type:Original Article
- Keywords:
Asthma;
vitamin D;
allergy
- MeSH:
Aged;
Asthma;
Body Mass Index;
Child;
Cholecalciferol;
Cross-Sectional Studies;
Eosinophils;
Hospitalization;
Humans;
Hypersensitivity;
Multivariate Analysis;
Respiratory Function Tests;
Vitamin D;
Vitamin D Deficiency;
Vitamins
- From:Allergy, Asthma & Immunology Research
2011;3(4):251-255
- CountryRepublic of Korea
- Language:English
-
Abstract:
PURPOSE: Asthma and other allergic disorders have increased over the past decades in nearly all nations. Many studies have suggested the role of vitamin D deficiency in both T-helper1 and T-helper2 diseases; however, the association between vitamin D, allergy, and asthma remains uncertain. In this study, the associations of 25-hydroxy vitamin D3 levels with asthma and with the severity of asthma were evaluated. METHODS: This cross-sectional study was conducted on 50 asthmatic children and 50 healthy controls aged 6-18 years. Serum 25-hydroxy vitamin D3 levels were determined and compared between the two groups. The relationship between serum vitamin D levels and pulmonary function test outcomes and eosinophil counts were examined in asthmatic patients. RESULTS: Univariate analysis of the relationship between asthma and vitamin D showed that decreased vitamin D levels were associated with significantly increased odds of asthmatic state (P=0.002). In a multivariate analysis after adjustment for age, body mass index, and sex, the relationship between vitamin D and asthma increased. In asthmatic patients, 25-hydroxy vitamin D levels had direct and significant correlations with both predicted FEV1 (R2=0.318; P=0.024) and FEV1/FVC (R2=0.315; P=0.026). There were no associations between vitamin D level and eosinophil counts, duration of disease, and the number of hospitalization or unscheduled visits in the previous year (P>0.05). CONCLUSIONS: These results showed that serum 25-hydroxy vitamin D levels were inversely associated with asthma, and there was a direct and significant relationship between vitamin D levels and pulmonary function test outcomes in asthmatic children. An interventional study in asthmatic patients with low serum vitamin D concentration may establish a causal relationship between asthma and vitamin D.
