Postnatal Development of Brain Natriuretic Peptide-immunoreactive Neuron in the Hypothalamus of the Rat.
10.11637/kjpa.2004.17.1.1
- Author:
Yoon Young CHUNG
1
;
Young Wook JEONG
;
Young Lan PARK
;
Jong Joong KIM
;
Jeong Seok MOON
;
Jin FU
;
Jae Wook OH
Author Information
1. Department of Anatomy, College of Medicine, Chosun University, Korea. yyjung@mail.chosun.ac.kr
- Publication Type:Original Article
- Keywords:
Brain natriuretic peptide;
Hypothalamus;
Rat;
Postnatal development;
Immunohistochemistry
- MeSH:
Adult;
Animals;
Arcuate Nucleus;
Brain*;
Dorsomedial Hypothalamic Nucleus;
Humans;
Hypothalamic Area, Lateral;
Hypothalamus*;
Immunohistochemistry;
Median Eminence;
Natriuretic Peptide, Brain;
Neurons*;
Neuropeptides;
Neurotransmitter Agents;
Paraventricular Hypothalamic Nucleus;
Parturition;
Rats*;
Supraoptic Nucleus;
Ventromedial Hypothalamic Nucleus
- From:Korean Journal of Physical Anthropology
2004;17(1):1-10
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Brain natriuretic peptide (BNP) is a neuropeptide, isolated from porcine brain that is homologous with atriopeptin. Magnocellular neurosecretory cells located in the paraventricular nucleus and supraoptic nucleus synthesize and secrete neurohormones. The purpose of this study was to investigate distribution of BNP immunoreactivity throughout the rat hypothalamus from the day of birth to 30 days and adult using immunoperoxidase and immunofluorescent staining. The first BNP immunoreactive neurons appeared in the paraventricular and supraoptic nucleus at P10. In adult, BNP immunoreactivity was widely distributed throughout regions of the hypothalamus including dorsomedial hypothalamic nucleus, ventromedial hypothalamic nucleus, arcuate nucleus and internal layer of median eminence. The intensity of BNP immunoreactivity was weak in almost all hypothalamic nuclei except the paraventricular and supraoptic nuclei. BNP immunoreactivity was first observed in the lateral hypothalamic area at P15. In retrochiasmatic supraoptic nucleus, BNP immunoreactivity was first observed at P20 and remarkably distributed in adult. In the present study, distinct localization of BNP immunoreactivity was in the hypothalamic cell bodies and fibers. Although the role of BNP in the brain is yet to be determined, these results indicate that BNP in the neurons of hypothalamus play important role in the regulation of a variety of neurosecretory functions as a neuromodulator during postnatal development of the hypothalamus.
