Change of peroxisome proliferator-activated receptor gamma expression pattern in the gerbil dentate gyrus after transient global cerebral ischemia.
10.5115/acb.2014.47.2.111
- Author:
Choong Hyun LEE
1
;
Moo Ho WON
Author Information
1. Department of Pharmacy, College of Pharmacy, Dankook University, Cheonan, Korea.
- Publication Type:Original Article
- Keywords:
PPAR gamma;
Ischemia-reperfusion;
Dentate gyrus;
Microglia
- MeSH:
Adipocytes;
Blotting, Western;
Brain Ischemia*;
Dentate Gyrus*;
Gerbillinae*;
Glucose;
Homeostasis;
Immunohistochemistry;
Lipid Metabolism;
Microglia;
Neurons;
PPAR gamma*
- From:Anatomy & Cell Biology
2014;47(2):111-116
- CountryRepublic of Korea
- Language:English
-
Abstract:
Peroxisome proliferator-activated receptor gamma (PPARgamma) has various actions including the regulation of adipocyte differentiation, lipid metabolism and glucose homeostasis. In the present study, we examined the changes of PPARgamma immunoreactivity and protein levels in the gerbil dentate gyrus (DG) after transient global cerebral ischemia using immunohistochemistry and western blot analysis. PPARgamma immunoreactivity was gradually increased from 1 day after ischemia-reperfusion. PPARgamma immunoreactivity, in accordance with protein level, was highest at 2 days after ischemia-reperfusion and was detected in microglia at this time. Thereafter, both PPARgamma immunoreactivity and protein level were decreased with time in the ischemic DG. These results indicate that PPARgamma may be related to the ischemia-induced microglial activation and neuronal damage/death in the DG after transient global cerebral ischemia.
