Increased Serum Cathepsin K in Patients with Coronary Artery Disease.
10.3349/ymj.2014.55.4.912
- Author:
Xiang LI
1
;
Yuzi LI
;
Jiyong JIN
;
Dehao JIN
;
Lan CUI
;
Xiangshan LI
;
Yanna REI
;
Haiying JIANG
;
Guangxian ZHAO
;
Guang YANG
;
Enbo ZHU
;
Yongshan NAN
;
Xianwu CHENG
Author Information
1. Department of Cardiology, Yanbian University Hospital, Yanji, Jilin P.R., China. lancui@ybu.edu.cn, chengxw0908@163.com
- Publication Type:Original Article ; Research Support, Non-U.S. Gov't
- Keywords:
Cathepsin K;
coronary artery disease;
biomarker;
high sensitive C-reactive protein;
myocardial ischemia
- MeSH:
Aged;
Biological Markers/blood;
C-Reactive Protein/metabolism;
Cathepsin K/*blood;
Coronary Artery Disease/*blood/metabolism;
Female;
Humans;
Male;
Middle Aged
- From:Yonsei Medical Journal
2014;55(4):912-919
- CountryRepublic of Korea
- Language:English
-
Abstract:
PURPOSE: Cathepsin K is a potent collagenase implicated in human and animal atherosclerosis-based vascular remodeling. This study examined the hypothesis that serum CatK is associated with the prevalence of coronary artery disease (CAD). MATERIALS AND METHODS: Between January 2011 and December 2012, 256 consecutive subjects were enrolled from among patients who underwent coronary angiography and percutaneous coronary intervention treatment. A total of 129 age-matched subjects served as controls. RESULTS: The subjects' serum cathepsin K and high sensitive C-reactive protein (hs-CRP) and high-density lipoprotein cholesterol were measured. The patients with CAD had significantly higher serum cathepsin K levels compared to the controls (130.8+/-25.5 ng/mL vs. 86.9+/-25.5 ng/mL, p<0.001), and the patients with acute coronary syndrome had significantly higher serum cathepsin K levels compared to those with stable angina pectoris (137.1+/-26.9 ng/mL vs. 102.6+/-12.9 ng/mL, p<0.001). A linear regression analysis showed that overall, the cathepsin K levels were inversely correlated with the high-density lipoprotein levels (r=-0.29, p<0.01) and positively with hs-CRP levels (r=0.32, p<0.01). Multiple logistic regression analyses shows that cathepsin K levels were independent predictors of CAD (odds ratio, 1.76; 95% confidence interval, 1.12 to 1.56; p<0.01). CONCLUSION: These data indicated that elevated levels of cathepsin K are closely associated with the presence of CAD and that circulating cathepsin K serves a useful biomarker for CAD.
