A Case of Toxic Epidermal Necrolysis Treated with Intravenous Immunoglobulin.
- Author:
Seung Yoon LEE
1
;
Yu Sung CHOI
;
Chung Eui YOU
;
Mi Youn PARK
;
Sook Ja SON
Author Information
1. Department of Dermatology, National Medical Center, Seoul, Korea. nmcderma@hanmail.net
- Publication Type:Case Report
- Keywords:
Intravenous immunoglobulin;
Toxic epidermal necrolysis
- MeSH:
Antigens, CD95;
Apoptosis;
Immunoglobulins*;
Immunoglobulins, Intravenous;
Keratinocytes;
Stevens-Johnson Syndrome*
- From:Korean Journal of Dermatology
2006;44(3):350-352
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Toxic epidermal necrolysis (TEN) is a rare, life-threatening, mucocutaneous drug reaction, which causes extensive epidermal detachment and serious complications involving ocular structures and internal organs. Recently, intravenous immunoglobulin (IVIG) was suggested to be effective in treating TEN through the blockage of Fas receptors which initiate keratinocyte apoptosis. Herein, we tried IVIG teratment (0.6 g/kg/day for 4 consecutive days) for a case of TEN. As a result, the progression of epidermal detachment was interrupted within 2 days and epithelialization was completed in 3 weeks without significant side effects.
