A Case of Congenital Rubella Syndrome.
- Author:
Jin Ho YU
1
;
Young Ho KWAK
;
He Sun JUNG
;
Song Yi NA
;
Hoan Jong LEE
;
Ki Joon SONG
Author Information
1. Department of Pediatrics, College of Medicine, Seoul National University.
- Publication Type:Case Report
- Keywords:
Congenital rubella;
Reverse transcription-nested polymerase chain reaction
- MeSH:
Growth and Development;
Humans;
Immunoglobulin G;
Immunoglobulin M;
Infant, Low Birth Weight;
Infant, Newborn;
Korea;
Lung;
Lymphatic Diseases;
Male;
Parturition;
Physical Examination;
Polymerase Chain Reaction;
Prenatal Diagnosis;
Purpura;
RNA;
Rubella;
Rubella Syndrome, Congenital*;
Rubella virus;
Thorax;
Thrombocytopenia
- From:Korean Journal of Infectious Diseases
1999;31(5):439-444
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Congenital rubella syndrome is a transplacental fetal infection with rubella virus and shows a wide spectrum of clinical expression from severe malformation to asymptomatic in the neonatal period. For the confirmation of congenital rubella, one of the following laboratory criteria should be present: isolation of rubella virus, demonstration of rubella-specific IgM antibody, or a rubella IgG antibody that persists and fails to drop at a rate of twofold dilution per month. Recently a reverse transcription-nested polymerase chain reaction (RT-nPCR) method for the prenatal diagnosis of rubella virus infection has been used. We experienced a case of congenital rubella in a 15- month old male who had suffered from respiratory difficulty. He had low birth weight. Thrombocytopenia was noticed shortly after his birth. He was transferred to our hospital because persistent respiratory difficulty had been developing since the age of one month. His growth and development were delayed. Physical examination revealed micrognathia, hepatosplenomegly, lymphadenopathy, and petechiae. Laboratory examination revealed a rubella specific IgM antibody. Chest X-ray suggested a chronic lung change. Rubella virus RNA was detected in the serum by RT-nPCR. This is the first case of congenital rubella, which was confirmed by the detection of rubella virus RNA, in Korea.
