Association between Healthy Eating Index-2010 and Fetuin-A Levels in Patients with Type 2 Diabetes: a Case-Control Study.
- Author:
Farzad ROSHANZAMIR
1
;
Maryam MIRAGHAJANI
;
Marjan MANSOURIAN
;
Reza GHIASVAND
;
Seyyed Morteza SAFAVI
Author Information
- Publication Type:Original Article
- Keywords: Healthy eating index-2010; Fetuin-A; Type 2 diabetes
- MeSH: alpha-2-HS-Glycoprotein*; Blood Glucose; Body Mass Index; Case-Control Studies*; Compliance; Diet; Eating*; Fasting; Healthy Volunteers; Homeostasis; Humans; Insulin Resistance; Lipoproteins; Motor Activity; Nutrition Policy; Transferases; Triglycerides; Waist Circumference
- From:Clinical Nutrition Research 2017;6(4):296-305
- CountryRepublic of Korea
- Language:English
- Abstract: The Healthy Eating Index-2010 (HEI-2010) assesses compliance with the 2010 Dietary Guidelines for Americans. Studies suggest that adherence to the HEI-2010 is related to lower the risk of type 2 diabetes (T2D). Fetuin-A, a novel biomarker for T2D, may play a linking role in the inverse association between HEI-2010 and T2D. Thus, a case-control analysis involving 107 patients with T2D and107 healthy subjects was conducted to determine the association between HEI-2010 and serum fetuin-A levels. The results of simple regression analysis showed that fetuin-A levels were positively associated with full name of body mass index (BMI) (p < 0.001), waist circumference (WC) (p < 0.001), fasting blood glucose (FBG) (p < 0.001), triglycerides (TG) (p = 0.003), gamma-glutamyl transferase (GGT) (p < 0.001), and homeostasis model assessment of insulin resistance (HOMA-IR) (p =0.001) and negatively associated with physical activity (PA) (p < 0.001), high-density lipoprotein (HDL) (p = 0.022), and HEI-2010 (p < 0.001) in all subjects. After controlling for confounders, the inverse association between fetuin-A and HEI-2010 remained significant in the subjects with T2D (β = −0.386; p < 0.001), 107 healthy controls (β = −0.237; p = 0.028), and all subjects (β = −0.298; p < 0.001). In conclusion, the present results suggested that higher quality diet assessed by HEI-2010 associates with lower serum fetuin-A levels in people with and without T2D. More studies are needed to confirm these findings.
