Clinical Features and Prognosis of Henoch-Schönlein Purpura in Children and Adults: A 13-Year Retrospective Study at a Single Centre.
10.3339/jkspn.2017.21.2.61
- Author:
Do Young JUNG
1
;
Ye Rim KWON
;
Min Heui YU
;
Mee Kyung NAMGOONG
Author Information
1. Department of Pediatrics, Yonsei University Wonju College of Medicine, Wonju, Korea. ngmk@yonsei.ac.kr
- Publication Type:Original Article
- Keywords:
Henoch-Schönlein Purpura;
Children;
Adult;
Clinical feature;
Prognosis
- MeSH:
Adult*;
Anemia;
Antistreptolysin;
C-Reactive Protein;
Child*;
Hematuria;
Humans;
Immunoglobulin A;
Immunoglobulin M;
Mycoplasma pneumoniae;
Nephrotic Syndrome;
Pneumonia, Mycoplasma;
Prognosis*;
Proteinuria;
Purpura*;
Renal Insufficiency, Chronic;
Retrospective Studies*;
Risk Factors;
Uric Acid
- From:Childhood Kidney Diseases
2017;21(2):61-68
- CountryRepublic of Korea
- Language:English
-
Abstract:
PURPOSE: To investigate differences in clinical features, blood/urinary findings, and prognosis in different age groups of patients with Henoch-Schönlein purpura (HSP). METHODS: A total of 469 patients with HSP were analyzed retrospectively from June 2003 to February 2016. We classified patients into child or adult groups based on their age. RESULTS: The adult group had more patients with anemia (child vs. adult; 7.5% vs. 16.4%), and higher immunoglobulin A (IgA) (30.0% vs. 50.0%) levels, C-reactive protein (34.2% vs. 54.0%) and uric acid (3.1% vs. 12.1%) levels than the child group. The child group was highly positive for Mycoplasma pneumoniae immunoglobulin M (IgM) (34.4%). More patients in the child group presented with high levels of antistreptolysin O (24.7% vs. 2.9%) and high C4 (11.5% vs. 4.2%). Low C3 (1.1% vs. 10.2%) levels, and renal involvement with gross hematuria (8.6% vs. 21.5%), nonnephrotic proteinuria (1.1% vs. 11.2%), and nephrotic syndrome (1.1% vs. 6.0%) were common in the adult group. Adults also had poorer renal outcomes [persistent hematuria/proteinuria (10.5% vs. 32.8%), and chronic kidney disease (0% vs. 11.2%)] than the child group. Risk factors for renal involvement such as older age and higher level of uric acid were only found in the child group. The risk factors for poor renal outcome were nephrotic syndrome in the child group and gross hematuria in the adult group. CONCLUSION: In this study, child and adult groups presented with different clinical manifestations of HSP. We found that risk factors for renal involvement included age and high uric acid level in the child group. Moreover, nephrotic syndrome in the child group and gross hematuria in the adult group increased the risk of poor renal outcome.
