Virus-associated Rhabdomyolysis in Children.
10.3339/jkspn.2017.21.2.89
- Author:
Jihye YOU
1
;
Jina LEE
;
Young Seo PARK
;
Joo Hoon LEE
Author Information
1. Department of Pediatrics, Asan Medical Center Children's Hospital, University of Ulsan College of Medicine, Seoul, Korea. pedkid@gmail.com
- Publication Type:Original Article
- Keywords:
Rhabdomyolysis;
Influenza B virus;
Paramyxoviridae infection;
Coronavirus;
Rhinovirus;
Children
- MeSH:
Alanine Transaminase;
Aspartate Aminotransferases;
Child*;
Coinfection;
Coronavirus;
Creatine Kinase;
Creatinine;
Humans;
Influenza B virus;
L-Lactate Dehydrogenase;
Leg;
Myoglobin;
Orthomyxoviridae;
Paramyxoviridae Infections;
Retrospective Studies;
Rhabdomyolysis*;
Rhinovirus
- From:Childhood Kidney Diseases
2017;21(2):89-93
- CountryRepublic of Korea
- Language:English
-
Abstract:
PURPOSE: Virus-associated rhabdomyolysis is very rare. We report 15 patients with rhabdomyolysis caused by various viruses. METHODS: Fifteen patients who were diagnosed with rhabdomyolysis and a viral infection were included in this study. Clinical, laboratory, and radiologic findings were evaluated through retrospective chart reviews. RESULTS: Chief complaints were severe bilateral lower leg pain and leg weakness. The median age was 5.7 years. The male:female ratio was 2:5. The viral infections were caused by influenza virus B, parainfluenza virus, and rhinovirus. One patient with influenza virus B had coinfection with coronavirus. Median initial laboratory values and ranges were as follows:serum creatinine, 0.4 (0.1-0.5) mg/dL; serum aspartate transaminase, 124 (48-1,098) IU/L; serum alanine transaminase, 30 (16-1,455) IU/L; serum creatine kinase, 2,965 (672-16,594) IU; serum lactate dehydrogenase, 400 (269-7,394) IU/L; serum myoglobin, 644 (314-3,867) ng/mL; urine myoglobin, 3 (3-10,431) ng/mL. All patients recovered without complications. CONCLUSION: This is the first report of the simultaneous occurrence of rhabdomyolysis caused by various viruses. This is also the first report of rhinovirus-associated rhabdomyolysis.
