Secondary Cutaneous Follicular B-Cell Lymphoma Associated with Erythematous Swelling on the Leg: A Case Report.
- Author:
Dong Joo KIM
1
;
Soo Kyung LEE
;
Un Ha LEE
;
Myoung Shin KIM
Author Information
1. Department of Dermatology, Sanggye Paik Hospital, Inje University College of Medicine, Seoul, Korea. etihwevol@naver.com
- Publication Type:Case Report
- Keywords:
Cutaneous follicular B-cell lymphoma;
Miliary and agminated lesions;
Secondary cutaneous B-cell lymphoma
- MeSH:
Antibodies, Monoclonal;
B-Lymphocytes*;
Biopsy;
Cyclin D1;
Cyclophosphamide;
Drug Therapy;
Germinal Center;
Humans;
Leg*;
Lymph Nodes;
Lymphocytes;
Lymphoma, B-Cell*;
Middle Aged;
Prednisone;
Skin;
Thigh;
Vincristine
- From:Korean Journal of Dermatology
2017;55(6):364-368
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Cutaneous follicular B-cell lymphoma (CFBCL) is defined as the neoplastic proliferation of germinal center cells confined to the skin. Secondary CFBCL demonstrates a more aggressive clinical course compared to the primary form. We report the case of a 45-year-old man who presented with a 15-day history of lesions on his right leg. Clinical examination revealed multiple erythematous miliary/agminated papules on the right proximal thigh with erythematous swollen patches on the right lower leg. Biopsy of a thigh lesion revealed a massive dermal lymphocytic infiltrate with a follicular pattern. Immunohistochemical staining revealed atypical lymphocytes, which strongly expressed CD20, CD10, Bcl-2, Bcl-6 and Ki-67 proteins, but not CD3 and Cyclin D1. Additionally, further studies revealed that this cutaneous lesion had originated from a retroperitoneal lymph node. We treated the patient with systemic chemotherapy using a cyclophosphamide, hydroxydaunorubicin, oncovin, and prednisone (CHOP) regimen and anti-CD20 monoclonal antibodies. This case illustrates a rarely reported example of secondary cutaneous follicular B-cell lymphoma showing peculiar clinical manifestations.
