Islet Transplantation vs. Pancreas Transplantation.
- Author:
Jae Hyeon KIM
1
;
Moon Kyu LEE
Author Information
1. Division of Endocrinology & Metabolism, Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea. leemk@skku.edu
- Publication Type:Original Article
- Keywords:
Islet transplantation;
Pancreas transplantation;
Diabetes;
Complication;
Survival
- MeSH:
Diabetes Complications;
Diabetes Mellitus;
Humans;
Insulin;
Islets of Langerhans Transplantation;
Kidney Failure, Chronic;
Pancreas;
Pancreas Transplantation;
Transplantation, Homologous;
Transplants
- From:Hanyang Medical Reviews
2009;29(2):186-192
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Transplantation of whole pancreas has emerged as an effective treatment modality for patients with diabetes mellitus, especially those with established end-stage renal disease. Although surgical and immunosuppressive advances have significantly improved allograft survival over a sustained period of time, there has been significant risk of surgical and post-operative complications. Islet transplantation has been considered as an attractive treatment option due to its less invasiveness and reduced peri-procedure morbidity, and because it can improve glycemic control in the type 1 diabetic patient with hypoglycemic unawareness. However, the revived enthusiasm regarding clinical islet transplantation after the landmark Edmonton trial has been decreased by the long-term results, although recent advances have led to an increased rate of achieving and maintaining insulin independence after islet transplantation. The aim of this review is to summarize current status and the outcome of whole pancreas and islet transplantation and their impact on patient's survival and long-term diabetic complications in patients with type 1 diabetes.
