Role of Nicotinic Acetylcholine Receptor on Efferent Inhibition in Cochlear Hair Cell.
10.7874/kja.2012.16.3.108
- Author:
Gi Jung IM
1
Author Information
1. Department of Otolaryngology-Head and Neck Surgery, Korea University College of Medicine, Seoul, Korea. logopas@korea.ac.kr
- Publication Type:Review
- Keywords:
Nicotinic receptor;
Hair cell;
Cochlea;
Acetylcholine;
Calcium
- MeSH:
Acetylcholine;
Calcium;
Cochlea;
Hair;
Permeability;
Potassium Channels, Calcium-Activated;
Receptors, Nicotinic
- From:Korean Journal of Audiology
2012;16(3):108-113
- CountryRepublic of Korea
- Language:English
-
Abstract:
The alpha9alpha10 nicotinic acetylcholine receptors (nAChRs) mediates efferent inhibition of hair cell function within the auditory sensory organ. Gating of the nAChRs leads to activation of calcium-dependent potassium channels to hyperpolarize the hair cell. In efferent system, main calcium providers to SK channel are nAChR and synaptic cistern, which contribution to efferent inhibition is different between avian and mammalian species. Calcium permeation is more effective in nAChRs of mammalian cochlea than avian cochlea, and mammalian calcium permeability of nAChRs is about 3 times more than avian hair cell. Thus, mammalian nAChRs is a main component of efferent inhibition in cochlear hair cell system.
