Clinical Significance of Early Detection of Esophageal Cancer in Patients with Head and Neck Cancer.
- Author:
Hyun LIM
1
;
Do Hoon KIM
;
Hwoon Yong JUNG
;
Eun Jeong GONG
;
Hee Kyong NA
;
Ji Yong AHN
;
Mi Young KIM
;
Jeong Hoon LEE
;
Kwi Sook CHOI
;
Kee Don CHOI
;
Ho June SONG
;
Gin Hyug LEE
;
Jin Ho KIM
Author Information
- Publication Type:Original Article
- Keywords: Esophageal neoplasms; Head and neck neoplasms; Early detection of cancer; Prognosis
- MeSH: Adolescent; Adult; Aged; Aged, 80 and over; Alcohol Drinking/adverse effects; Carcinoma, Squamous Cell/*diagnosis/mortality/*pathology/*secondary; Early Detection of Cancer/*statistics & numerical data; Esophageal Neoplasms/*diagnosis/mortality/*secondary; Female; Head and Neck Neoplasms/mortality/*pathology; Humans; Male; Middle Aged; Multivariate Analysis; Prognosis; Retrospective Studies; Risk Factors; Survival Rate; Young Adult
- From:Gut and Liver 2015;9(2):159-166
- CountryRepublic of Korea
- Language:English
- Abstract: BACKGROUND/AIMS: The efficacy of surveillance for esophageal squamous cell neoplasia (ESCN) in patients with head and neck squamous cell carcinoma (HNSCC) remains controversial. Our study aimed to provide clinical data concerning the necessity of surveillance for detecting early ESCN in patients with HNSCC. METHODS: We retrospectively reviewed the data from 714 patients who were pathologically confirmed as having HNSCC (n=236 oral cavity cancers, 137 oropharyngeal cancers, 87 hypopharyngeal cancers, and 254 laryngeal cancers). RESULTS: Of 714 patients, during a median follow-up of 31 months, 48 ESCNs (37 synchronous and 11 metachronous) were detected in 36 patients (5%). Fifteen synchronous lesions (40.3%) were early ESCN, whereas nine metachronous lesions (81.8%) were early ESCN. The 3-year survival rates of HNSCC only and HNSCC combined with ESCN were 71.2% and 48.2%, respectively (p<0.001). Among 36 patients with ESCN, the 3-year survival rates for early and advanced ESCN were 77.7% and 21.7%, respectively (p=0.01). In the multivariate analysis, alcohol consumption and hypopharyngeal cancer were significant factors associated with the development of ESCN. CONCLUSIONS: HNSCC patients with early ESCN were similar in prognosis with patients without ESCN, in contrast to patients with advanced ESCN. Therefore, surveillance for the early detection of ESCN in patients with HNSCC, especially in alcohol drinkers and those with hypopharyngeal cancer, is warranted.
