A Case of Aconite Poisoning Successfully Recovered after Intravenous Fat Emulsion Therapy.
- Author:
Hee Jun SHIN
1
;
Hoon LIM
Author Information
1. Department of Emergency Medicine, College of Medicine, Soon Chun Hyang University Hospital, Bucheon, Korea. 43210@schmc.ac.kr
- Publication Type:Case Report
- Keywords:
Aconitine;
Aconitum;
Antidotes;
Intravenous fat emulsions
- MeSH:
Aconitine;
Aconitum*;
Amiodarone;
Antidotes;
Calcium Channels;
Cardiotoxicity;
Clinical Protocols;
Fat Emulsions, Intravenous;
Flowers;
Humans;
Poisoning*;
Ranunculaceae;
Sodium Channels;
Tachycardia
- From:Journal of The Korean Society of Clinical Toxicology
2016;14(1):60-65
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Aconitum is a genus of various species of flowering plants that belongs to the Family Ranunculaceae. Most Aconitum sp. have extremely toxic alkaloid substances such as aconitine, mesaconitine and hypaconitine. Among these substances, aconitine can cause fatal cardiotoxicity by activating sodium channels followed by calcium channels in myocardial cells. Even though there have been various therapeutic plans suggested comprising antidotes based on diverse case reports and studies, there is no confirmatory treatment protocol for aconite poisoning. Here, we report an aconite poisoning patient who had refractory ventricular tachyarrhythmia that did not respond to intravenous amiodarone therapies even though they were sustained for over 2 hours, but showed successful recovery following intravenous fat emulsions (IFE) therapy.
