Clinical Manifestations and Outcomes of Treatment in Cytomegalovirus Endotheliitis.
10.3341/jkos.2016.57.6.863
- Author:
Young Jun KIM
1
;
Woong Sun YOO
;
Yong Seop HAN
;
Inyoung CHUNG
;
Seong Wook SEO
;
Ji Myong YOO
;
Jong Moon PARK
;
Min Chul CHO
;
Seong Jae KIM
Author Information
1. Department of Ophthalmology, Gyeongsang National University School of Medicine, Jinju, Korea. Maya12kim@naver.com
- Publication Type:Original Article
- Keywords:
Cytomegalovirus;
Endotheliitis;
Ganciclovir
- MeSH:
Anterior Chamber;
Aqueous Humor;
Cytomegalovirus*;
Follow-Up Studies;
Ganciclovir;
Humans;
Inflammation;
Intraocular Pressure;
Keratoplasty, Penetrating;
Medical Records;
Polymerase Chain Reaction;
Recurrence;
Visual Acuity
- From:Journal of the Korean Ophthalmological Society
2016;57(6):863-875
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
PURPOSE: To elucidate the clinical manifestations of cytomegalovirus (CMV) endotheliitis, and evaluate the outcomes of treatment in CMV endotheliitis. METHODS: We reviewed the medical records of 7 patients (8 eyes) who were diagnosed with CMV endotheliitis via a polymerase chain reaction (PCR) of aqueous humor and were treated with ganciclovir. RESULTS: Eight eyes of 7 patients were followed for a mean of 17.8 months. One patient had bilateral corneal endotheliitis. All eyes had coin-shaped keratoprecipitates and mild anterior chamber inflammation (1+~2+). All eyes had an absence of anterior segment inflammation 3 weeks after ganciclovir treatment. Following treatment, the mean visual acuity improved significantly from 0.60 ± 0.40 (log MAR) at baseline to 0.18 ± 0.18 (log MAR) at last follow-up. The mean intraocular pressure (IOP) decreased significantly from 30 mm Hg at baseline to 12 mm Hg at last visit. Two eyes had a recurrence of corneal endotheliitis, where one underwent penetrating keratoplasty and the other was treated with intravitreal ganciclovir injection. CONCLUSIONS: Patients with increased IOP and coin-shaped keratoprecipitates are suspected to have CMV endotheliitis, and PCR of aqueous humor is needed to diagnose CMV endotheliitis. More than 6 weeks of ganciclovir treatment might be effective for CMV endotheliitis and may help prevent recurrence.
