Event-Related Potential P3a and P3b using 3-Stimulus Auditory "Oddball" Paradigm in the Patients with Schizophrenia.
- Author:
Yong Tak JIN
1
;
E Jin PARK
;
Ji Min NAM
;
Sang Ick HAN
;
Yang Whan JEON
Author Information
1. Department of Neuropsychiatry, Eunhye Hospital, Incheon, Korea.
- Publication Type:Original Article
- Keywords:
P300;
P3a;
P3b;
Schizophrenia;
3-stimulus auditory paradigm
- MeSH:
Ambulatory Care Facilities;
Evoked Potentials*;
Humans;
Noise;
Schizophrenia*
- From:Journal of Korean Neuropsychiatric Association
2005;44(5):568-575
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
OBJECTIVES: Using 3-stimulus auditory "oddball" paradigm reflecting fronto/central and temporo/parietal functions simultaneously, we examined patients with schizophrenia. METHODS: Fifteen patients with schizophrenia from outpatient clinic and fifteen normal controls from hospital staffs were recruited for the study. To elicit P3a and P3b, 3-stimulus auditory oddball paradigm was employed. The 3-stimulus auditory oddball paradigm was composed of standard tone (1,000 Hz, 75 dB, 80%), target tone (2,000 Hz, 75 dB, 10%) and distracter (White noise, 95 dB, 10%). RESULTS: P3a and P3b were prominent in fronto/central and temporo/parietal areas, respectively, in both schizophrenics and normal controls. The P300 amplitude in patients with schizophrenia was reduced across P3a and P3b (p<0.01). The P300 latency in patients with schizophrenia was delayed across P3a and P3b (p<0.01). CONCLUSION: These results were consistent with frontal and temporo-parietal lobe dysfunctions in schizophrenics. The 3-stimulus auditory paradigm could be applied for patients with schizophrenia and useful for further exploration the disorder.
