Effects of intravenous immune globulin on the peripheral lymphocyte phenotypes in Kawasaki disease.
10.3349/ymj.1996.37.5.357
- Author:
Hong Kyu LEE
1
;
Dong Soo KIM
;
Geun Woong NOH
;
Ki Young LEE
Author Information
1. Department of Pediatrics, Yonsei University College of Medicine, Seoul, Korea.
- Publication Type:Original Article ; Clinical Trial ; Randomized Controlled Trial ; Research Support, Non-U.S. Gov't
- Keywords:
Kawasaki disease;
intravenous immune globulin;
T cell;
B cell;
CD5+ B cell
- MeSH:
Child, Preschool;
Female;
Human;
Immunoglobulins, Intravenous/*therapeutic use;
Immunophenotyping;
Infant;
Lymphocyte Subsets/*immunology;
Male;
Mucocutaneous Lymph Node Syndrome/immunology/*therapy;
Support, Non-U.S. Gov't
- From:Yonsei Medical Journal
1996;37(5):357-363
- CountryRepublic of Korea
- Language:English
-
Abstract:
The effect of intravenous immune globulin (IVIG) on the lymphocyte phenotypes in acute Kawasaki disease (KD) was studied in a random trial of IVIG-and-aspirin versus aspirin-alone. Before therapy, patients in each treatment group had an increased percentage of B cells, and a decreased percentage of T cells, CD4 T cells, CD8 T cells and CD5+ B cells. There was no significant difference in immunologic parameters between the two groups measured before therapy. Patients treated with IVIG-and-aspirin had by the fourth day developed a highly-significant increase in T cells, CD4 T cells and CD8 T cells and a decrease in B cells. Despite the decrease of B cells, there were significant increases in CD5+ B cells in both treatment groups. However, the degree of increase in the IVIG-and-aspirin treated group was significantly more noticeable than that in the aspirin-alone treated group. These findings indicate that treatment with IVIG restores the T- and B- cell abnormalities, especially CD5+ B-cell abnormalities found in patients with acute KD.
